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Review of organic functional groups: introduction to medicinal organic chemistry
Author
Publisher
Wolters Kluwer/Lippincott Williams & Wilkins Health
Publication Date
c2012
Language
English
Description
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Table of Contents
From the Book - 5th ed.
Preface
1. Water Solubility and Chemical Bonding
Van der Waals Attraction (Forces)
Dipole-Dipole Bonding (Hydrogen Bond)
Ionic Attraction
Ion-Dipole Bonding
2. Alkanes (C n H 2n+2
3. Alkenes (C n H 2n
Cycloalkanes: Alkene Isomers
4. Aromatic Hydrocarbons
5. Haolgenated Hydrocarbons
Case Studies
6. Alcohols
Case Studies
7. Phenols
Case Studies
8. Ethers and Thioethers
Ethers
Thioethers
Case Studies
9. Aldehydes and Ketones
Case Studies
10. Amines
Amines-General
Quaternary Ammonium Salts
Case Studies
11. Carboxylic Acids
Case Studies
12. Functional Derivatives of Carboxylic Acids
Esters
Amides
Carbonates, Carbamates, and Ureas
Amidines and Guanidines
Case Studies
13. Sulfonic Acids and Sulfonamides
Sulfonic Acids
Sulfonamides
Case Studies
14. Nitrogen Functional Groups
Nitro Groups
Nitrate Group
Nitrite Group
Oximes
Hydrazone/Hydrazine/Hydrazide
Case Studies
15. Heterocycles
Three-Membered Ring Heterocycles
Four-Membered Ring Heterocycles
Five-Membered Ring Heterocycles
Five-Membered Ring Heterocycles with Two or More Heteroatoms
Six-Membered Ring Heterocycles
Saturated Six-Membered Ring Heterocycles
Seven- and Eight-Membered Ring Heterocycles
Bicyclic Heterocycles: Five-Membered Ring Plus Six-Membered Ring
Bicyclic Heterocycles: Six-Membered Ring Plus Six-Membered Ring
Bicyclic Heterocycles: Six-Membered Ring Plus Seven-Membered Ring
Tricyclic Heterocycles
Case Studies
16. Oligonucleotides and Nucleic Acids
Case Studies
17. Proteins
Case Studies
18. Predicting Water Solubility
The Role of Chemical Bonding between Dissimilar Organic Functional Groups
Empiric Method for Predicting Water Solubility
Analytic Method for Calculating Water Solubility
Case Studies
A. Stereoisomerism-Asymmetric Molecules
B. Acidity and Basicity
Definitions of Acids and Bases
Relative Strengths of Acids and Bases
Reaction of an Acid with a Base in Water
Acidic and Basic Organic Function Groups
C. Drug Metabolism
Metabolic Enzymes
D. Learning Objectives
Glossary
Index
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ISBN
9781608310166
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